Maison Mm6 Margiela Martin Mules Black qB7azqWR
printed leather, laminated effect, two-tone pattern, round toeline, square heel, wooden heel, leather lining, rubber sole, no appliqués, contains non-textile parts of animal origin, mules. Soft Leather
Margiela Mules Black Maison Martin Mm6 Margiela Mm6 Mules Martin Black Maison Margiela Martin Mm6 Mules Black Maison
2002 Sep 27;297(5590):2275-9.

Abstract

Celiac Sprue, a widely prevalent autoimmune disease of the small intestine, is induced in genetically susceptible individuals by exposure to dietary gluten. A 33-mer peptide was identified that has several characteristics suggesting it is the primary initiator of the inflammatory response to gluten in Celiac Sprue patients. In vitro and in vivo studies in rats and humans demonstrated that it is stable toward breakdown by all gastric, pancreatic, and intestinal brush-border membrane proteases. The peptide reacted with tissue transglutaminase, the major autoantigen in Celiac Sprue, with substantially greater selectivity than known natural substrates of this extracellular enzyme. It was a potent inducer of gut-derived human T cell lines from 14 of 14 Celiac Sprue patients. Homologs of this peptide were found in all food grains that are toxic to Celiac Sprue patients but are absent from all nontoxic food grains. The peptide could be detoxified in in vitro and in vivo assays by exposure to a bacterial prolyl endopeptidase, suggesting a strategy for oral peptidase supplement therapy for Celiac Sprue.

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