Sneakers Koio 'Gavia' Collective Collective Koio White 'Gavia' XF1wqFrg
Our trek inspired low-top in pristine pebble grain calf leather. The Gavia, with its rugged yet refined mountaineering grommets, is named for one of the highest mountain passes in the Italian Alps. Gold-tone eyelets gives our classic whites an elegant edge. Made by hand in the Marche region of Italy, constructed with Italian pebble grain calf leather, lined with buttery soft calf leather, outfitted with metal mountaineering eyelets, outfitted with durable, lightweight rubber outsoles by our friends at Margom and finished with hand-painted edges. This item is unisex. This item fits large, please select the next size down.
Collective White 'Gavia' Collective Sneakers Koio 'Gavia' Koio White Collective 'Gavia' 'Gavia' Koio Sneakers Koio Collective Collective White Sneakers Koio Koio 'Gavia' 'Gavia' Collective
2002 Sep 27;297(5590):2275-9.


Celiac Sprue, a widely prevalent autoimmune disease of the small intestine, is induced in genetically susceptible individuals by exposure to dietary gluten. A 33-mer peptide was identified that has several characteristics suggesting it is the primary initiator of the inflammatory response to gluten in Celiac Sprue patients. In vitro and in vivo studies in rats and humans demonstrated that it is stable toward breakdown by all gastric, pancreatic, and intestinal brush-border membrane proteases. The peptide reacted with tissue transglutaminase, the major autoantigen in Celiac Sprue, with substantially greater selectivity than known natural substrates of this extracellular enzyme. It was a potent inducer of gut-derived human T cell lines from 14 of 14 Celiac Sprue patients. Homologs of this peptide were found in all food grains that are toxic to Celiac Sprue patients but are absent from all nontoxic food grains. The peptide could be detoxified in in vitro and in vivo assays by exposure to a bacterial prolyl endopeptidase, suggesting a strategy for oral peptidase supplement therapy for Celiac Sprue.

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