Waterproof Terradora Keen Gray Shoes Neutral Black Gargoyle wgCBq
Whether you are on the trail or in the city Keen Terradora Waterproof hiking shoe will keep you dry comfortable and steady on your feet all day long. Lightweight breathable mesh and synthetic upper. Designed on a women's specific last for a comfortable fit. KEEN.DRY waterproof and breathable textile membrane keeps your feet dry and comfortable. Cleansport NXT technology for natural odor control for a fresh foot environment. Contoured heel lock for a secure fit. Breathable mesh lining. Removable dual-density PU footbed for underfoot comfort and support. Low-density EVA midsole provides excellent underfoot support and shock absorption. ESS stability shank for reliable support and stability. Non-marking rubber outsole with 4mm multidirectional lugs for excellent traction. Imported. Measurements: Weight: 11 oz Product measurements were taken using size 7 width B - Medium. Please note that measurements may vary by size. Weight of footwear is based on a single item not a pair.
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2002 Sep 27;297(5590):2275-9.

Abstract

Celiac Sprue, a widely prevalent autoimmune disease of the small intestine, is induced in genetically susceptible individuals by exposure to dietary gluten. A 33-mer peptide was identified that has several characteristics suggesting it is the primary initiator of the inflammatory response to gluten in Celiac Sprue patients. In vitro and in vivo studies in rats and humans demonstrated that it is stable toward breakdown by all gastric, pancreatic, and intestinal brush-border membrane proteases. The peptide reacted with tissue transglutaminase, the major autoantigen in Celiac Sprue, with substantially greater selectivity than known natural substrates of this extracellular enzyme. It was a potent inducer of gut-derived human T cell lines from 14 of 14 Celiac Sprue patients. Homologs of this peptide were found in all food grains that are toxic to Celiac Sprue patients but are absent from all nontoxic food grains. The peptide could be detoxified in in vitro and in vivo assays by exposure to a bacterial prolyl endopeptidase, suggesting a strategy for oral peptidase supplement therapy for Celiac Sprue.

[Indexed for MEDLINE]
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